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The dual role of cellular senescence in human tumor progression and therapy

19 Aug 2024

Abstract excerpt

Cellular senescence, one of the hallmarks of cancer, is characterized by cell cycle arrest and the loss of most normal cellular functions while acquiring a hypersecretory, proinflammatory phenotype. The function of senescent cells in cancer cells varies depending on the cellular conditions. Before the occurrence of cancer, senescent cells act as a barrier to prevent its development. But once cancer has occurred,...

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PMID: 39161800
DOI: 10.1002/mco2.695

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