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Cellular senescence: a double-edged sword in cancer therapy

12 Sept 2023

Abstract excerpt

Over the past few decades, cellular senescence has been identified in cancer patients undergoing chemotherapy and radiotherapy. Senescent cells are generally characterized by permanent cell cycle arrest as a response to endogenous and exogenous stresses. In addition to exiting the cell cycle process, cellular senescence also triggers profound phenotypic changes such as senescence-associated secretory phenotype...

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PMID: 37771436
DOI: 10.3389/fonc.2023.1189015

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