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Therapeutic strategies targeting cellular senescence for cancer and other diseases

13 Feb 2024

Abstract excerpt

Cellular senescence occurs in response to endogenous or exogenous stresses and is characterized by stable cell cycle arrest, alterations in nuclear morphology and secretion of proinflammatory factors, referred to as the senescence-associated secretory phenotype (SASP). An increase of senescent cells is associated with the development of several types of cancer and aging-related diseases. Therefore, senolytic...

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PMID: 38366629
DOI: 10.1093/jb/mvae015

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