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The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence

1 Dec 2020

Abstract excerpt

Cellular senescence is traditionally considered as stable cell cycle arrest state with other phenotypic alterations including the production of an array of cytokines and growth factors. Cancer cells undergo senescence in response to chemotherapeutic agents, radiotherapy and molecular targeted therapy. This form of senescence is termed therapy-induced senescence (TIS) and represents a desirable target in cancer...

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PMID: 33408525
DOI: 10.2147/cmar.s285083

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