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Article

Evolutionary dependency of cancer mutations in gene pairs inferred by nonsynonymous-synonymous mutation ratios.

Genome medicine - 19 Aug 2024

Han Dong-Jin, Kim Sunmin, Lee Seo-Young, Moon Youngbeen, Kang Su Jung, Yoo Jinseon, Jeong Hye Young, Cho Hae Jin, Jeon Jeong Yang, Sim Byeong Chang, Kim Jaehoon, Lee Seungho, Xi Ruibin, Kim Tae-Min

Abstract excerpt

BACKGROUND: Determining the impact of somatic mutations requires understanding the functional relationship of genes acquiring mutations; however, it is largely unknown how mutations in functionally related genes influence each other. METHODS: We employed non-synonymous-to-synonymous or dNdS ratios to evaluate the evolutionary dependency (ED) of gene pairs, assuming a mutation in one gene of a gene pair can affect...

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PMID: 39160568
DOI: 10.1186/s13073-024-01376-7
PMCID: PMC11331682

Genes

IDH1
ATRX
BRAF
CTCF
EGFR
IDH2
KRAS
PRSS1
TCF7L2

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