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Article

Integrated multi-omics data analyses for exploring the co-occurring and mutually exclusive gene alteration events in colorectal cancer.

Human mutation - 1 Sept 2020

Zhou Yuan, Cheng Xiaoqing, Zhang Fenglan, Chen Qingqing, Chen Xinyu, Shen Yaojia, Lai Chong, Kota Vishnu G, Sun Wenjie, Huang Qiong, Yuan Ying, Wang Jin, Lai Maode, Zhang Dandan

Abstract excerpt

Co-occurring and mutually exclusive gene alteration events are helpful for understanding carcinogenesis but systematic screening for such events is quite limited. We conducted pairwise screening tests to identify "hit pairs" in colorectal cancer (CRC) by utilizing the cross-omics data from The Cancer Genome Atlas (TCGA). Numerous hit pairs involving somatic mutations, copy number variations, and DNA methylation...

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PMID: 32485022
DOI: 10.1002/humu.24059

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