Article
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain.
PLoS genetics - 13 May 2010
Gibbs J Raphael, van der Brug Marcel P, Hernandez Dena G, Traynor Bryan J, Nalls Michael A, Lai Shiao-Lin, Arepalli Sampath, Dillman Allissa, Rafferty Ian P, Troncoso Juan, Johnson Robert, Zielke H Ronald, Ferrucci Luigi, Longo Dan L, Cookson Mark R, Singleton Andrew B
Abstract excerpt
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We present a set of integrated experiments that investigate the effects of common genetic variability on DNA methylation and mRNA expression in four human brain regions each from 150 individuals (600 samples total). We find an abundance of genetic...
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