Article
Structure of Tau filaments in Prion protein amyloidoses.
Acta neuropathologica - 1 Aug 2021
Hallinan Grace I, Hoq Md Rejaul, Ghosh Manali, Vago Frank S, Fernandez Anllely, Garringer Holly J, Vidal Ruben, Jiang Wen, Ghetti Bernardino
Abstract excerpt
In human neurodegenerative diseases associated with the intracellular aggregation of Tau protein, the ordered cores of Tau filaments adopt distinct folds. Here, we analyze Tau filaments isolated from the brain of individuals affected by Prion-Protein cerebral amyloid angiopathy (PrP-CAA) with a nonsense mutation in the PRNP gene that leads to early termination of translation of PrP (Q160Ter or Q160X), and...
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