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Article

Integrative eQTL and Mendelian Randomization Analyses with Experimental Validation Prioritize Genetic Candidate Biomarkers for Crohn's Disease.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Zhang Xinwei, Liu Lin, Xu Wenyu, Li Guangxin, Qin Qiu, Zhang Jinan

Abstract excerpt

INTRODUCTION: Crohn's disease (CD) is a chronic, idiopathic inflammatory bowel disease. Understanding the genetic and immunological basis of CD can lead to better therapeutic strategies. METHODS: We employed publicly available datasets from the Gene Expression Omnibus (GEO) database to identify instrumental variables through expression quantitative trait loci (eQTL) analysis and conducted two-sample Mendelian...

Read the complete abstract on PubMed

Topics

Crohn Disease
Humans
Quantitative Trait Loci
Mendelian Randomization Analysis
Genetic Markers
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Databases, Genetic

Genome-Wide Association Study

Gene Expression Profiling

Source

Open in PubMed Open full text

Identifiers

PMID: 42059218
DOI: 10.2174/0118715303433720260216212725
PMCID: PMC13629158

Genes

BATF2
FCGR2A
MCTP1
SERPINB9
SMIM1
SNX30

Provenance

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