Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome‐Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol

29 Mar 2019

Abstract excerpt

Allopurinol, which lowers uric acid (UA) concentration, is increasingly being recognized for its benefits in cardiovascular and renal disease. However, response to allopurinol is variable. We gathered samples from 4,446 multiethnic subjects for a genome‐wide association study of allopurinol response. Consistent with previous studies, we observed that the Q141K variant in ABCG2 (rs2231142), which encodes the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to Gout, Hyperuricemia, Uric Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV/AIDS drug development and treatment

Source

Identifiers

PMID: 30924126
DOI: 10.1002/cpt.1439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome‐Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for AllopurinolPMID 30924126Read ↗

Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.Semantic proximity Read ↗

A Genomewide Association Study of Oxypurinol Concentrations in Patients Treated with AllopurinolSemantic proximity Read ↗

Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics.Semantic proximity Read ↗

A systematic review of single nucleotide polymorphisms affecting allopurinol pharmacokinetics and serum uric acid level.Semantic proximity Read ↗

Association between ABCG2 polymorphisms and allopurinol response in gout patients: a systematic review and meta-analysis.Semantic proximity Read ↗

The impact of genetic variability in urate transporters on oxypurinol pharmacokineticsSemantic proximity Read ↗

Association of rare and common genetic variants in MOCOS with inadequate response to allopurinol.Semantic proximity Read ↗

ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approachesSemantic proximity Read ↗

Association between ABCG2 rs2231142 and poor response to allopurinol: replication and meta-analysis.Semantic proximity Read ↗

Metabolic Interactions of Purine Derivatives with Human ABC Transporter ABCG2: Genetic Testing to Assess Gout RiskSemantic proximity Read ↗

Pharmacogenetic Perspective for Optimal Gout ManagementSemantic proximity Read ↗

Analysis of ABCG2 gene rs2231142 single nucleotide polymorphism and risk factors in hyperuricemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.