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Article

The impact of genetic variability in urate transporters on oxypurinol pharmacokinetics

18 Nov 2022

Abstract excerpt

The genetic determinants of the allopurinol dose-concentration relationship have not been extensively studied. We aimed to clarify what factors, including genetic variation in urate transporters, influence oxypurinol pharmacokinetics (PKs). A population PK model for oxypurinol was developed with NONMEM (version 7.3). The influence of urate transporter genetic variants for ABCG2 (rs2231142 and rs10011796),...

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PMID: 36398357
DOI: 10.1111/cts.13460

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