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Article

Genetic variability and population diversity of the human SLCO (OATP) transporter family

22 Oct 2018

Abstract excerpt

Organic anion transporting polypeptides (OATP) encoded by the SLCO gene family constitute clinically important transporters involved in the disposition of endogenous compounds and many commonly prescribed drugs, including statins, methotrexate and antihypertensive medications. Common genetic polymorphisms in SLCO genes are known to affect OATP function and modulate efficacy and safety of OATP substrates. However,...

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PMID: 30359687
DOI: 10.1016/j.phrs.2018.10.017

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