Article
Cytogenetic abnormalities in NPM1-mutated acute myeloid leukemia.
Leukemia & lymphoma - 1 Aug 2022
Fu Weijia, Huang Aijie, Xu Lili, Peng Yanni, Gao Lei, Chen Li, Chen Jie, Tang Gusheng, Yang Jianmin, Ni Xiong
Abstract excerpt
NPM1mut acute myeloid leukemia (AML) has been identified as a distinct entity of myeloid neoplasms according to the 2017 European LeukemiaNet (ELN) guidelines. It confers a favorable prognosis regardless of cytogenetic abnormalities. We evaluated 418 newly diagnosed AML patients to test the validity of this hypothesis. Seventy-four patients with NPM1mut AML showed a good response to induction and a relatively...
Topics
- Abnormal Karyotype
- Chromosome Aberrations
- Humans
- Leukemia, Myeloid, Acute
- Mutation
- Nuclear Proteins
- Nucleophosmin
- Prognosis
- fms-Like Tyrosine Kinase 3