Frequency and impact of somatic co-occurring mutations on post-transplant outcomes in acute myeloid leukemia: a multicenter registry analysis on behalf of the EBMT ALWP.

doi:10.1038/s41409-025-02770-4

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Frequency and impact of somatic co-occurring mutations on post-transplant outcomes in acute myeloid leukemia: a multicenter registry analysis on behalf of the EBMT ALWP.

Bone marrow transplantation - 1 Mar 2026

Bazarbachi Ali, Galimard Jacques-Emmanuel, Abou Dalle Iman, Labopin Myriam, Sanz Jaime, Huang He, Mayer Jiri, Solano Carlos, Lioure Bruno, Griskevicius Laimonas, Maertens Johan, Itälä-Remes Maija, Kaare Ain, Gallego-Hernanz Maria-Pilar, Bug Gesine, Ribera Josep-Maria, Gadisseur Alain, Schmid Christoph, Kwon Mi, Poiré Xavier, Coccia Paola, Jurado Chacón Manuel, Baron Frédéric, Craddock Charles, Brissot Eolia, Nagler Arnon, Ciceri Fabio, Mohty Mohamad

Abstract excerpt

Acute myeloid leukemia (AML) includes genetically defined subsets. In allogeneic hematopoietic cell transplantation (allo-HCT), the frequency and prognosis of gene-gene interactions may differ from those of patients treated with chemotherapy alone. In this study, adult patients (N = 952) with AML allografted between 2015 and 2023, with available next generation sequencing (NGS) at diagnosis were included. Most...

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Identifiers

PMID: 41345260
DOI: 10.1038/s41409-025-02770-4

Genes

CR1
DNMT3A
FLT3
IDH2
NPM1
RUNX1
TET2
TP53
ASXL1
IDH1
NRAS
SRSF2

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