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Article

PKM2 ablation enhanced retinal function and survival in a preclinical model of retinitis pigmentosa.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2020

Zhang Ethan, Ryu Joseph, Levi Sarah R, Oh Jin Kyun, Hsu Chun Wei, Cui Xuan, Lee Ting-Ting, Wang Nan-Kai, Lima de Carvalho Jose Ronaldo, Tsang Stephen H

Abstract excerpt

Retinitis pigmentosa (RP) is a neurodegenerative disorder that causes irreversible vision loss in over 1.5 million individuals world-wide. The genetic heterogeneity of RP necessitates a broad therapy that is able to provide treatment in a gene- and mutation- non-specific manner. In this study, we identify the therapeutic benefits of metabolic reprogramming by targeting pyruvate kinase M2 (PKM2) in a Pde6β...

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Identifiers

PMID: 32342224
DOI: 10.1007/s00335-020-09837-1
PMCID: PMC9578386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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