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Article

Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration.

Journal of translational medicine - 20 Dec 2016

Golestaneh Nady, Chu Yi, Cheng Shuk Kei, Cao Hong, Poliakov Eugenia, Berinstein Daniel M

Abstract excerpt

BACKGROUND: Study of age related macular degeneration (AMD) has been hampered by lack of human models that represent the complexity of the disease. Here we have developed a human in vitro disease model of AMD to investigate the underlying AMD disease mechanisms. METHODS: Generation of iPSCs from retinal pigment epithelium (RPE) of AMD donors, age-matched normal donors, skin fibroblasts of a dry AMD patient, and...

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Topics

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Share to Induced Pluripotent Stem Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Share to Phagocytosis

Share to Reactive Oxygen Species

Share to Retinal Pigment Epithelium

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Source

Open in PubMed Open full text

Identifiers

PMID: 27998274
DOI: 10.1186/s12967-016-1101-8
PMCID: PMC5175395

Genes

RPE
PGC
SIRT1
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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