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Integrated single-cell and bulk transcriptomic analysis identifies a novel macrophage subtype associated with poor prognosis in breast cancer

27 Mar 2025

Abstract excerpt

BACKGROUND: Tumor-associated macrophages (TAMs) are pivotal components of the breast cancer (BC) tumor microenvironment (TME), significantly influencing tumor progression and response to therapy. However, the heterogeneity and specific roles of TAM subpopulations in BC remain inadequately understood. METHODS: We performed an integrated analysis of single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing...

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PMID: 40148933
DOI: 10.1186/s12935-025-03750-w

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