Aryl Hydrocarbon Receptor Knockout Accelerates PanIN Formation and Fibro-Inflammation in a Mutant Kras -Driven Pancreatic Cancer Model.

doi:10.1097/MPA.0000000000002357

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Article

Aryl Hydrocarbon Receptor Knockout Accelerates PanIN Formation and Fibro-Inflammation in a Mutant Kras -Driven Pancreatic Cancer Model.

Pancreas - 1 Sept 2024

Walcheck Morgan T, Schwartz Patrick B, Carrillo Noah D, Matkowskyj Kristina A, Nukaya Manabu, Bradfield Christopher A, Ronnekleiv-Kelly Sean M

Abstract excerpt

OBJECTIVES: The pathogenesis of pancreas cancer (PDAC) remains poorly understood, hindering efforts to develop a more effective therapy for PDAC. Recent discoveries show the aryl hydrocarbon receptor (AHR) plays a crucial role in the development of several cancers and can be targeted for therapeutic effect. However, its involvement in the pathogenesis of PDAC remains unclear. To address this gap, we evaluated the...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38696422
DOI: 10.1097/MPA.0000000000002357
PMCID: PMC11321943

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