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Article

Exploring pleiotropy in Mendelian randomisation analyses: What are genetic variants associated with 'cigarette smoking initiation' really capturing?

Genetic epidemiology - 1 Jan 2025

Reed Zoe E, Wootton Robyn E, Khouja Jasmine N, Richardson Tom G, Sanderson Eleanor, Davey Smith George, Munafò Marcus R

Abstract excerpt

Genetic variants used as instruments for exposures in Mendelian randomisation (MR) analyses may have horizontal pleiotropic effects (i.e., influence outcomes via pathways other than through the exposure), which can undermine the validity of results. We examined the extent of this using smoking behaviours as an example. We first ran a phenome-wide association study in UK Biobank, using a smoking initiation genetic...

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Identifiers

PMID: 39099143
DOI: 10.1002/gepi.22583
PMCID: PMC7616876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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