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Article

Genetic architecture of four smoking behaviors using partitioned SNP heritability.

Addiction (Abingdon, England) - 1 Sept 2021

Evans Luke M, Jang Seonkyeong, Hancock Dana B, Ehringer Marissa A, Otto Jacqueline M, Vrieze Scott I, Keller Matthew C

Abstract excerpt

BACKGROUND AND AIMS: Although genome-wide association studies have identified many loci that influence smoking behaviors, much of the genetic variance remains unexplained. We characterized the genetic architecture of four smoking behaviors using single nucleotide polymorphism (SNP) heritability (h2SNP ). This is an estimate of narrow-sense heritability specifically estimating the proportion of phenotypic...

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PMID: 33620764
DOI: 10.1111/add.15450
PMCID: PMC8759147

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