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Article

The influence of CLEC5A on early macrophage-mediated inflammation in COPD progression.

Cellular and molecular life sciences : CMLS - 4 Aug 2024

Li Qingyang, Liu Yu, Wang Xiaoyu, Xie Chengshu, Mei Xinyue, Cao Weitao, Guan Wenhui, Lin Xinqing, Xie Xiaohong, Zhou Chengzhi, Yi Erkang

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is a complex syndrome with poorly understood mechanisms driving its early progression (GOLD stages 1-2). Elucidating the genetic factors that influence early-stage COPD, particularly those related to airway inflammation and remodeling, is crucial. This study analyzed lung tissue sequencing data from patients with early-stage COPD (GSE47460) and smoke-exposed mice. We...

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Identifiers

PMID: 39097839
DOI: 10.1007/s00018-024-05375-0
PMCID: PMC11335254

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