Article

Computational Deconvolution of Cell Type-Specific Gene Expression in COPD and IPF Lungs Reveals Disease Severity Associations

2024-03-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are debilitating diseases associated with divergent histopathological changes in the lungs. At present, due to cost and technical limitations, profiling cell types is not practical in large epidemiology cohorts (n>1000). Here, we used computational deconvolution to identify cell types in COPD a...

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Literature Corpus work: 871f39a9-dbd0-557d-92cc-68c0d79f2bd0
DOI: 10.1101/2024.03.26.24304775

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