Article

Single-cell transcriptomics reveal cell type-specific molecular changes and altered intercellular communications in chronic obstructive pulmonary disease

2021-02-25

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is a common and heterogeneous respiratory disease, the molecular complexity of which remains poorly understood, as well as the mechanisms by which aging and smoking facilitate COPD development. Here, using single-cell RNA sequencing of more than 65,000 cells from COPD and age-stratified control lung tissues of donors with different smoking histories, we identified monoc...

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Literature Corpus work: 5c3ac397-f5b5-5074-b22b-598fae84ece2
DOI: 10.1101/2021.02.23.432590

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