Article
From early-onset asthma to chronic obstructive pulmonary disease: potential mediating proteins and therapeutic targets.
Briefings in bioinformatics - 3 May 2026
Jiang Yuhan, Guo Ju, Wang Yifan, Guo Run, Wei Yongjian, Li Tianchun, Wang Xuelin, Xia Ruiwen, Li Wanyi, Zou Yingxue, Yang Hongxi
Abstract excerpt
BACKGROUND AND OBJECTIVE: Early-onset asthma (EOA) significantly increases the risk of chronic obstructive pulmonary disease (COPD), yet the causal mechanisms and molecular mediators underlying this progression remain poorly understood. Multi-omics integration provides a powerful framework for prioritizing potential mediating proteins and disease-specific therapeutic candidates. METHODS: This study integrated...
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