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Article

Single-cell transcriptomics highlights immunological dysregulations of monocytes in the pathobiology of COPD

20 Dec 2022

Abstract excerpt

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common respiratory disease, whose pathogenetic complexity was strongly associated with aging/smoking and poorly understood. METHODS: Here we performed single-cell RNA sequencing (scRNA-seq) analysis of 66,610 cells from COPD and age-stratified control lung tissues of donors with different smoking histories to prioritize cell types most perturbed in...

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PMID: 36539833
DOI: 10.1186/s12931-022-02293-2

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