Article
Leveraging lung tissue transcriptome to uncover candidate causal genes in COPD genetic associations.
Human molecular genetics - 15 May 2018
Lamontagne Maxime, Bérubé Jean-Christophe, Obeidat Ma'en, Cho Michael H, Hobbs Brian D, Sakornsakolpat Phuwanat, de Jong Kim, Boezen H Marike, Nickle David, Hao Ke, Timens Wim, van den Berge Maarten, Joubert Philippe, Laviolette Michel, Sin Don D, Paré Peter D, Bossé Yohan
Abstract excerpt
Causal genes of chronic obstructive pulmonary disease (COPD) remain elusive. The current study aims at integrating genome-wide association studies (GWAS) and lung expression quantitative trait loci (eQTL) data to map COPD candidate causal genes and gain biological insights into the recently discovered COPD susceptibility loci. Two complementary genomic datasets on COPD were studied. First, the lung eQTL dataset...
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