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Genetic variants of FER and SULF1 in the fibroblast-related genes are associated with non-small-cell lung cancer survival.

International journal of cancer - 1 Jun 2025

Lu Guojun, Liu Hongliang, Wang Huilin, Luo Sheng, Du Mulong, Christiani David C, Wei Qingyi

Abstract excerpt

Fibroblasts are important components in the tumor microenvironment and can affect tumor progression and metastasis. However, the roles of genetic variants of the fibroblast-related genes (FRGs) in the prognosis of non-small-cell lung cancer (NSCLC) patients have not been reported. Therefore, we investigated the associations between 26,544 single nucleotide polymorphisms (SNPs) in 291 FRGs and survival of NSCLC...

Topics

Humans
Polymorphism, Single Nucleotide
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Female
Male
Middle Aged
Sulfotransferases
Prognosis
Aged
Arylsulfotransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fibroblasts

Biomarkers, Tumor

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 39707607
DOI: 10.1002/ijc.35305
PMCID: PMC11971011

Genes

FER
SULF1
HLCS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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