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Article

Focus on CCL19: A Mendelian randomization study on genetic evidence of immune cells influencing osteoarthritis severity via inflammatory proteins.

Medicine - 22 May 2026

Chen Shuai, Gan Yudong, Wang Feng, Jin Yan, Wu Zhongxiong, Liu Zenghui, Wu Tong, Zhang Zhongzi

Abstract excerpt

Osteoarthritis (OA) is a prevalent degenerative joint disorder whose pathogenesis involves immune-inflammatory regulation. Immune cells may influence OA progression by modulating inflammatory proteins; however, the underlying mechanisms remain inadequately understood. This study used Mendelian randomization (MR) analysis to investigate the causal effects of immune cells on OA. Additionally, it evaluated the...

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Share to CD4 gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Inflammation

Share to Mendelian Randomization Analysis

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 42175426
DOI: 10.1097/MD.0000000000048948
PMCID: PMC13200936

Genes

CCL19
CD33
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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