Article
The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase.
Nature communications - 24 Aug 2024
Kawai Takafumi, Morioka Shin, Miyata Haruhiko, Andriani Rizki Tsari, Akter Sharmin, Toma Gabriel, Nakagawa Tatsuya, Oyama Yuki, Iida-Norita Rie, Sasaki Junko, Watanabe Masahiko, Sakimura Kenji, Ikawa Masahito, Sasaki Takehiko, Okamura Yasushi
Abstract excerpt
Voltage-sensing phosphatase (VSP) exhibits voltage-dependent phosphatase activity toward phosphoinositides. VSP generates a specialized phosphoinositide environment in mammalian sperm flagellum. However, the voltage-sensing mechanism of VSP in spermatozoa is not yet characterized. Here, we found that VSP is activated during sperm maturation, indicating that electric signals in immature spermatozoa are essential....
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