Article
Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis.
Annals of neurology - 1 Jul 2018
Jia Xiaoming, Madireddy Lohith, Caillier Stacy, Santaniello Adam, Esposito Federica, Comi Giancarlo, Stuve Olaf, Zhou Yuan, Taylor Bruce, Kilpatrick Trevor, Martinelli-Boneschi Filippo, Cree Bruce A C, Oksenberg Jorge R, Hauser Stephen L, Baranzini Sergio E
Abstract excerpt
OBJECTIVE: Primary progressive multiple sclerosis (PPMS) causes accumulation of neurological disability from disease onset without clinical attacks typical of relapsing multiple sclerosis (RMS). However, whether genetic variation influences the disease course remains unclear. We aimed to determine whether mutations causative of neurological disorders that share features with multiple sclerosis (MS) contribute to...
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