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DNA methyltransferase-1 in acute myeloid leukaemia: beyond the maintenance of DNA methylation

15 Jul 2022

Abstract excerpt

DNA methylation is considered an essential epigenetic event during leukaemogenesis and the emergence of drug resistance, which is primarily regulated by DNA methyltransferases. DNA methyltransferase-1 (DNMT1) is one of the members of DNA methyltransferases, in charge of maintaining established methylation. Recently, DNMT1 is shown to promote malignant events of cancers through the epigenetic and non-epigenetic...

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PMID: 35838271
DOI: 10.1080/07853890.2022.2099578

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