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Quercetin Promotes the M1-to-M2 Macrophage Phenotypic Switch During Liver Fibrosis Treatment by Modulating the JAK2/STAT3 Signaling Pathway.

Recent patents on anti-cancer drug discovery - 1 Jan 2026

Sun Dongqi, Zhou Xiaoling, Wu Teng, Li Zepeng, Huang Shigao, Peng Zheng

Abstract excerpt

OBJECTIVE: To investigate the underlying mechanism by which quercetin (Que) regulates macrophage polarization and its subsequent therapeutic effect on liver fibrosis, an important pathological precondition for hepatocellular carcinoma (HCC). METHODS: In vitro experiments were performed on the RAW264.7 mouse macrophage line. After the induction of M1-type macrophages with LPS, the effects of Que on cell...

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Identifiers

PMID: 39360530
DOI: 10.2174/0115748928318948240920044716

Genes

JAK2
STAT3
CCL4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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