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Article

Pristimerin suppresses the phenotypic switch of vascular smooth muscle cells in atherosclerosis through inhibiting the activation of JAK2/STAT3 pathway.

Molecular immunology - 1 Oct 2026

Liu Xiwen, Li Jiyu, Qu Lifeng, Qiao Tong

Abstract excerpt

AIM: The aim of our research was to investigate the potential effect of pristimerin (Pris) on atherosclerosis (AS), and clarify its underlying molecular mechanisms. METHODS: The effect of Pris on atherosclerotic lesions were assessed by using HE staining and Oil red O staining. Moreover, serum lipid profiles also detected using the commercial reagent kits. Inflammatory factors expression was determined employing...

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Topics

Animals
Janus Kinase 2
STAT3 Transcription Factor
Atherosclerosis
Muscle, Smooth, Vascular
Signal Transduction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

Myocytes, Smooth Muscle

Pentacyclic Triterpenes

Male

Phenotype

Cell Proliferation

Mice, Inbred C57BL

Cell Movement

Lipoproteins, LDL

Cells, Cultured

Triterpenes

Inflammation

Source

Identifiers

PMID: 42641439
DOI: 10.1016/j.molimm.2026.08.011

Genes

JAK2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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