Article

Interplay Between KLF4, STAT, IRF and NF-κB in VSMC and Macrophage Plasticity During Vascular Inflammation and Atherosclerosis

2025-10-03

Abstract excerpt

Atherosclerosis is characterized by atherosclerotic plaque formation in large and medium vessels, mediated by endothelial cell (EC) dysfunction, altered contractility of Vascular Smooth Muscle Cells (VSMC) and recruitment of blood leukocytes to the injured vascular endothelium. These include macrophages (MØ), T lymphocytes and dendritic cells, which drive the production of many inflammatory mediators and the proce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95b56a5a-a026-50cf-af9f-3c510f3a72d4
DOI: 10.20944/preprints202510.0228.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interplay Between KLF4, STAT, IRF and NF-κB in VSMC and Macrophage Plasticity During Vascular Inflammation and AtherosclerosisDOI 10.20944/preprints202510.0228.v1Read

STAT1 and IRF8 in Vascular Inflammation and Cardiovascular Disease: Diagnostic and Therapeutic PotentialSemantic proximity Read

Quercetin Attenuates KLF4-Mediated Phenotypic Switch of VSMCs to Macrophage-like Cells in Atherosclerosis: A Critical Role for the JAK2/STAT3 Pathway.Semantic proximity Read

BEYOND CONTRACTILITY: PHENOTYPIC SWITCHING OF VASCULAR SMOOTH MUSCLE CELLS IN ATHEROSCLEROSIS.Semantic proximity Read

NLRP3 Inflammasome Activation Controls Vascular Smooth Muscle Cells Phenotypic Switch in Atherosclerosis.Semantic proximity Read

Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic PotentialSemantic proximity Read

Role of Krüppel-like factor 4 in phenotypic switching and proliferation of vascular smooth muscle cells.Semantic proximity Read

The role of transcription factors in the pathogenesis and therapeutic targeting of vascular diseasesSemantic proximity Read

Regulation of Macrophage Activation and Differentiation in AtherosclerosisSemantic proximity Read

Myeloid Krüppel-like factor 4 deficiency augments atherogenesis in ApoE-/- mice--brief report.Semantic proximity Read

Molecular Pathways Regulating Macrophage Polarization: Implications for AtherosclerosisSemantic proximity Read

Innate Immune Pathways in Atherosclerosis – from Signaling to Long-Term Epigenetic ReprogrammingSemantic proximity Read

Macrophage polarization and function: new prospects for fibrotic diseaseSemantic proximity Read