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Article

The integrity of the corticospinal tract and corpus callosum, and the risk of ALS: univariable and multivariable Mendelian randomization.

Scientific reports - 26 Jul 2024

Wu Jieying, Zhang Gan, Zhang Linjing, Ye Shan, Huang Tao, Fan Dongsheng

Abstract excerpt

Studies suggest that amyotrophic lateral sclerosis (ALS) compromises the integrity of white matter fiber tracts, primarily affecting motor fibers. However, it remains uncertain whether the integrity of these fibers influences the risk of ALS. We performed bidirectional two-sample Mendelian randomization (MR) and multivariable MR analyses to evaluate the associative relationships between the integrity of fiber...

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Identifiers

PMID: 39060317
DOI: 10.1038/s41598-024-68374-y
PMCID: PMC11282093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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