Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bidirectional Mendelian randomization study of causal associations between white-matter structural connectivity and multiple sclerosis.

The International journal of neuroscience - 1 Jul 2026

Yu Zhenxing, Chen Haijun, Zhang Zhipeng, Xiong Yuhan, Zha Jing, Deng Lei, Zhang Xianbin

Abstract excerpt

BACKGROUND: Multiple sclerosis (MS) is associated with widespread network disruption, but whether specific white-matter structural connectivity (WMSC) phenotypes contribute causally to MS susceptibility remains unclear. METHODS: We performed bidirectional two-sample Mendelian randomization (MR) using genome-wide association study (GWAS) summary statistics for 206 tractography-derived WMSC phenotypes (UK Biobank;...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connectome
Share to Diffusion Tensor Imaging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Multiple Sclerosis

Share to Nerve Net

Share to Neural Pathways

Share to White Matter

Source

Identifiers

PMID: 41975653
DOI: 10.1080/00207454.2026.2658643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bidirectional Mendelian randomization study of causal associations between white-matter structural connectivity and multiple sclerosis.PMID 41975653Read ↗

Genetic architecture of the white matter connectome of the human brainSemantic proximity Read ↗

Bidirectional two-sample Mendelian randomization analyses support causal relationships between structural and diffusion imaging-derived phenotypes and the risk of major neurodegenerative diseases.Semantic proximity Read ↗

Assessment of bidirectional relationships between brain imaging-derived phenotypes and stroke: a Mendelian randomization study.Semantic proximity Read ↗

Causal relationship between multiple sclerosis and cortical structure: a Mendelian randomization study.Semantic proximity Read ↗

The integrity of the corticospinal tract and corpus callosum, and the risk of ALS: univariable and multivariable Mendelian randomization.Semantic proximity Read ↗

Genetic architecture of the white matter connectome of the human brainSemantic proximity Read ↗

Mendelian randomization analysis implicates bidirectional associations between brain imaging-derived phenotypes and ischemic stroke.Semantic proximity Read ↗

Unveiling causal relationship between white matter tracts and psychiatric disordersSemantic proximity Read ↗

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging-Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases.Semantic proximity Read ↗

Deriving Mendelian Randomization-Based Causal Networks of Brain Imaging Phenotypes and Bipolar Disorder.Semantic proximity Read ↗

Causal association of COVID-19 with brain structure changes: Findings from a non-overlapping 2-sample Mendelian randomization study.Semantic proximity Read ↗

Causal relationships between alzheimer's disease genetics and brain connectivity alterations: a multi-modal mendelian randomization study with transcriptomic validation of 191 rs-fMRI and 635 DTI neuroimaging traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.