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Article

Investigation of the causal relationship between ALS and autoimmune disorders: a Mendelian randomization study.

BMC medicine - 2 Nov 2022

Alipour Paria, Senkevich Konstantin, Ross Jay P, Spiegelman Dan, Manousaki Despoina, Dion Patrick A, Rouleau Guy A

Abstract excerpt

BACKGROUND: Epidemiological studies have reported an association between amyotrophic lateral sclerosis (ALS) and different autoimmune disorders. This study aims to explore the causal relationship between autoimmune disorders and ALS using Mendelian randomization (MR). METHODS: To test the genetically predicted effects of liability towards immune-related outcomes on ALS risk, we used summary statistics from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36320012
DOI: 10.1186/s12916-022-02578-9
PMCID: PMC9628014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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