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Article

Investigating the causal relationship between multimodal brain imaging-derived phenotypes and insomnia: A Mendelian randomization study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 23 Dec 2025

Gu Hanqing, Jiang Ying, Zhang Wentong, Li Weiwei, He Jiejin, Liu Sheng, Li Yong, He Chuan

Abstract excerpt

BACKGROUND: Insomnia has been consistently linked to alterations in both the structural and functional characteristics of the brain, yet the precise causal mechanisms underlying these associations remain incompletely understood. METHODS: We used genome-wide association study (GWAS) summary data for 3,935 multimodal IDPs from 22,138 individuals and insomnia data from 283,595 individuals. Univariate bidirectional...

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Identifiers

PMID: 41432849
DOI: 10.1007/s10072-025-08619-4

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