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Article

Leukocyte telomere length and amyotrophic lateral sclerosis: a Mendelian randomization study.

Orphanet journal of rare diseases - 14 Dec 2021

Xia Kailin, Zhang Linjing, Zhang Gan, Wang Yajun, Huang Tao, Fan Dongsheng

Abstract excerpt

BACKGROUND: Observational studies have suggested that telomere length is associated with amyotrophic lateral sclerosis (ALS). However, whether this association is causal remains unclear. In this study, we aimed to explore the causal relationship between leukocyte telomere length (LTL) and ALS by a two-sample Mendelian randomization (MR) approach. Single-nucleotide polymorphisms (SNPs) for LTL were identified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34906191
DOI: 10.1186/s13023-021-02135-2
PMCID: PMC8670150

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