Article
Genetic evidence for the causal linkage between telomere length and aortic aneurysm risk: A Mendelian randomisation study.
European journal of clinical investigation - 1 Nov 2023
Zhang Ronghuai, Wu Min, Ma Meijuan, Liu Bo, Zhang Xuejun, Wei Na, Wang Ting, Lv Ying, Xu Cuixiang, Wang Junkui, Zhang Yulian, Liu Fuqiang
Abstract excerpt
BACKGROUND: Evidence of a clear causal relationship between telomere length and aortic aneurysms is limited by the potential for confounding or reverse causation effects. In this study, we used a Mendelian randomisation (MR) approach to investigate this putative causal association. METHODS: In total, 118 telomere length-associated single-nucleotide polymorphisms, identified in 472,174 individuals of European...
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