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Article

Role of MTHFR, IRF6, PAX7 and TP63 SNPs in susceptibility to non-syndromic orofacial cleft, a candidate gene study in a Portuguese population.

Orthodontics & craniofacial research - 1 Dec 2024

Mendes João, Guimarães Adriana Rocha, Ribeiro Joana Martins, Oliveiros Bárbara, Mesquita Luís Alcides, Fernandes Maria Helena, do Vale Francisco José Fernandes, Silva Henriqueta Coimbra

Abstract excerpt

BACKGROUND: Non-syndromic orofacial cleft (NSOC) is a complex phenotype, involving multiple genetic and environmental factors. Association studies exploring the genetic susceptibility to this prevalent oral malformation show variability of results in different populations. Using a candidate gene approach, we aimed to verify the role of four single-nucleotide polymorphisms (SNPs) in the susceptibility to NSOC in...

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PMID: 39049717
DOI: 10.1111/ocr.12838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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