Article
Association between IRF6, TP63, GREM1 Gene Polymorphisms and Non-Syndromic Orofacial Cleft Phenotypes in Vietnamese Population: A Case-Control and Family-Based Study.
Genes - 25 Oct 2023
Pham Loc Nguyen Gia, Niimi Teruyuki, Suzuki Satoshi, Nguyen Minh Duc, Nguyen Linh Cao Hoai, Nguyen Tuan Duc, Hoang Kien Ai, Nguyen Duc Minh, Sakuma Chisato, Hayakawa Toko, Hiyori Makino, Natsume Nagana, Furukawa Hiroo, Imura Hideto, Akashi Junko, Ohta Tohru, Natsume Nagato
Abstract excerpt
This study aims to identify potential variants in the TP63-IRF6 pathway and GREM1 for the etiology of non-syndromic orofacial cleft (NSOFC) among the Vietnamese population. By collecting 527 case-parent trios and 527 control samples, we conducted a stratified analysis based on different NSOFC phenotypes, using allelic, dominant, recessive and over-dominant models for case-control analyses, and family-based...
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