MTHFR rs2274976 polymorphism is a risk marker for nonsyndromic cleft lip with or without cleft palate in the Brazilian population.

doi:10.1002/bdra.23199

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MTHFR rs2274976 polymorphism is a risk marker for nonsyndromic cleft lip with or without cleft palate in the Brazilian population.

Birth defects research. Part A, Clinical and molecular teratology - 1 Jan 2014

de Aquino Sibele Nascimento, Hoshi Ryuichi, Bagordakis Elizabete, Pucciarelli Maria Giulia Rezende, Messetti Ana Camila, Moreira Helenara, Bufalino Andreia, Borges Andréa, Rangel Ana Lucia, Brito Luciano Abreu, Oliveira Swerts Mario Sergio, Martelli-Junior Hercilio, Line Sergio R, Graner Edgard, Reis Sílvia R A, Passos-Bueno Maria Rita, Coletta Ricardo D

Abstract excerpt

BACKGROUND: Polymorphisms within the MTHFR (rs2274976) and MTHFD1 (rs2236225) genes were previously associated with maternal susceptibility for having an offspring with nonsyndromic cleft lip with or without cleft palate (NSCL/P) in the Brazilian population. However, as the genotypes of the patients with NSCL/P were not evaluated, it is not clear whether the effects are associated with maternal or offspring...

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Methylenetetrahydrofolate Reductase (NADPH2)

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PMID: 24254627
DOI: 10.1002/bdra.23199

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MTHFR
MTHFD1

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