Article

Functionally overlapping variants control TB susceptibility in Collaborative Cross mice

2019-09-28

Abstract excerpt

Host genetics plays an important role in determining the outcome of Mycobacterium tuberculosis (Mtb) infection. We previously found that Collaborative Cross mouse strains differ in their susceptibility to Mtb, and that the CC042/GeniUnc (CC042) strain suffered from a rapidly progressive disease and failed to produce the protective cytokine, IFN γ , in the lung. Here, we used parallel genetic and immunological ap...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e7accdec-8371-511e-b8c9-84f67c44179f
DOI: 10.1101/785725

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functionally overlapping variants control TB susceptibility in Collaborative Cross miceDOI 10.1101/785725Read

Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice.Semantic proximity Read

Systems genetics uncover new loci containing functional gene candidates in <i>Mycobacterium tuberculosis</i> -infected Diversity Outbred miceSemantic proximity Read

Host-pathogen genetic interactions underlie tuberculosis susceptibilitySemantic proximity Read

Immunological roads diverged: mapping tuberculosis outcomes in mice.Semantic proximity Read

Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred miceSemantic proximity Read

Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severitySemantic proximity Read

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse miceSemantic proximity Read

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice.Semantic proximity Read

Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity.Semantic proximity Read

The Collaborative Cross mouse model for dissecting genetic susceptibility to infectious diseases.Semantic proximity Read

Host genetic background is a barrier to broadly effective vaccine–mediated protection against tuberculosisSemantic proximity Read

Multiple genetic loci influence vaccine-induced protection against Mycobacterium tuberculosis in genetically diverse miceSemantic proximity Read