Retrospective analysis of Braak stage- and APOE4 allele-dependent associations between MR spectroscopy and markers of tau and neurodegeneration in cognitively unimpaired elderly.

doi:10.1016/j.neuroimage.2024.120742

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Article

Retrospective analysis of Braak stage- and APOE4 allele-dependent associations between MR spectroscopy and markers of tau and neurodegeneration in cognitively unimpaired elderly.

NeuroImage - 15 Aug 2024

Chen Anna M, Gajdošík Martin, Ahmed Wajiha, Ahn Sinyeob, Babb James S, Blessing Esther M, Boutajangout Allal, de Leon Mony J, Debure Ludovic, Gaggi Naomi, Gajdošík Mia, George Ajax, Ghuman Mobeena, Glodzik Lidia, Harvey Patrick, Juchem Christoph, Marsh Karyn, Peralta Rosemary, Rusinek Henry, Sheriff Sulaiman, Vedvyas Alok, Wisniewski Thomas, Zheng Helena, Osorio Ricardo, Kirov Ivan I

Abstract excerpt

PURPOSE: The pathological hallmarks of Alzheimer's disease (AD), amyloid, tau, and associated neurodegeneration, are present in the cortical gray matter (GM) years before symptom onset, and at significantly greater levels in carriers of the apolipoprotein E4 (APOE4) allele. Their respective biomarkers, A/T/N, have been found to correlate with aspects of brain biochemistry, measured with magnetic resonance...

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PMID: 39029606
DOI: 10.1016/j.neuroimage.2024.120742
PMCID: PMC11404707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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