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Article

Somatic CpG hypermutation is associated with mismatch repair deficiency in cancer.

Molecular systems biology - 1 Sept 2024

Flynn Aidan, Waszak Sebastian M, Weischenfeldt Joachim

Abstract excerpt

Somatic hypermutation in cancer has gained momentum with the increased use of tumour mutation burden as a biomarker for immune checkpoint inhibitors. Spontaneous deamination of 5-methylcytosine to thymine at CpG dinucleotides is one of the most ubiquitous endogenous mutational processes in normal and cancer cells. Here, we performed a systematic investigation of somatic CpG hypermutation at a pan-cancer level. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39026103
DOI: 10.1038/s44320-024-00054-5
PMCID: PMC11369196

Genes

MSH2
MSH6
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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