Article

Mutation and Microsatellite Burden Predict Response to PD-1 Inhibition in Children with Germline DNA Replication Repair Deficiency

2021-02-15

Abstract excerpt

<title>Abstract</title> <p>Cancers arising from germline DNA mismatch-repair or polymerase-proofreading deficiencies (MMRD and PPD) in children harbour the highest mutational and microsatellite insertion/deletion (MS-indel) burden in humans and are lethal due to inherent resistance to chemo-irradiation. Although immune checkpoint inhibitors (ICI) have failed to benefit children in previous studies, we hypothesize...

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Literature Corpus work: d6475cdf-1ec3-5f97-8074-5f494a4d32cd
DOI: 10.21203/rs.3.rs-155292/v1

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