Article

Gene expression signature for predicting homologous recombination deficiency in triple-negative breast cancer

2022-06-09

Abstract excerpt

Triple-negative breast cancers (TNBCs) are a subset of breast cancers that have remained difficult to treat. Roughly 1 in 10 of TNBCs arise in individuals with pathogenic variants in BRCA1 or BRCA2 , and treating BRCA-associated TNBCs with PARP inhibitors results in improved survival. A proportion of TNBCs arising in non-carriers of BRCA pathogenic variants have genomic features that are similar to BRCA carrie...

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Literature Corpus work: 6cdfe176-115a-5212-9b22-0f1fbc1e87d7
DOI: 10.1101/2022.06.08.495296

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