Article
Globally defining the effects of mutations in a picornavirus capsid.
eLife - 12 Jan 2021
Mattenberger Florian, Latorre Victor, Tirosh Omer, Stern Adi, Geller Ron
Abstract excerpt
The capsids of non-enveloped viruses are highly multimeric and multifunctional protein assemblies that play key roles in viral biology and pathogenesis. Despite their importance, a comprehensive understanding of how mutations affect viral fitness across different structural and functional attributes of the capsid is lacking. To address this limitation, we globally define the effects of mutations across the capsid...
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