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Fitness effects of mutations to SARS-CoV-2 proteins

1 Jul 2023

Abstract excerpt

Knowledge of the fitness effects of mutations to SARS-CoV-2 can inform assessment of new variants, design of therapeutics resistant to escape, and understanding of the functions of viral proteins. However, experimentally measuring effects of mutations is challenging: we lack tractable lab assays for many SARS-CoV-2 proteins, and comprehensive deep mutational scanning has been applied to only two SARS-CoV-2...

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PMID: 37727875
DOI: 10.1093/ve/vead055

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